Fernando,
I'm not really sure I would call this genotype selection. It sounds more
like a form of post-zygotic reproductive isolation mechanism that helps
prevent species from interbreeding by making the resultant hybrids sterile
or at least reducing their reproductive success. For example - although
horses can breed with donkeys to produce viable offspring, mules, the mules
are sterile because they cannot form gametes for exactly the reason you
mention. Horses and donkeys have different numbers of chromosomes and the
mules end up with an odd number of chromosomes. When it comes time for
meiosis in the mule, synapsis cannot occur, and no viable gametes are
produced. If I've missed something in your argument, let me know.
Liane Cochran-Stafira